New insights into the role of renal resident cells in the pathogenesis of lupus nephritis
The Korean Journal of Internal Medicine
;
: 284-289, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-713546
ABSTRACT
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage. In this review, we describe recent advances in the role of renal resident cells, including podocytes, mesangial cells, and epithelial cells, in the pathogenesis of lupus nephritis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autoanticorpos
/
Doenças Autoimunes
/
Produtos Biológicos
/
Nefrite Lúpica
/
Mortalidade
/
Células Epiteliais
/
Células Mesangiais
/
Podócitos
/
Inflamação
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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