The Role of B Cells in Transplantation Rejection / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 1-6, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-713610
ABSTRACT
B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular helper T cells. B cells also function as antigen-presenting cells for alloreactive T cells, resulting in the activation of alloreactive T cells. Conversely, the frequency of regulatory B cells increases under inflammatory conditions and suppresses the rejection process. Here, the differential roles of the major B cell subpopulations (B-1, follicular B, marginal zone B, and regulatory B cells) involved in transplantation rejection are discussed together with their interaction with T cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos B
/
Linfócitos T
/
Linfócitos T Auxiliares-Indutores
/
Linfócitos B Reguladores
/
Rejeição de Enxerto
/
Isoantígenos
/
Complexo Principal de Histocompatibilidade
/
Anticorpos
/
Diversidade de Anticorpos
/
Células Apresentadoras de Antígenos
Idioma:
Inglês
Revista:
The Journal of the Korean Society for Transplantation
Ano de publicação:
2018
Tipo de documento:
Artigo
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