Prognosis of preoperative positron emission tomography uptake in hepatectomy patients
Annals of Surgical Treatment and Research
; : 183-189, 2018.
Article
em En
| WPRIM
| ID: wpr-713945
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Preoperative F-18-fluoro-2-deoxy-glucose positron emission tomography (18F-FDG PET) imaging results appear to predict tumor recurrence and patient survival. The present study compared outcomes between PET-positive and PET-negative groups with HBV-related hepatocellular carcinoma (HCC) who underwent curative hepatectomy and assessed the prognostic value of positive PET-CT for HCC recurrence and death. METHODS: This study included patients who underwent liver resection of solitary HCC between 2007 and 2014 based on preoperative radiological images. There were 133 patients in the PET-positive group and 93 in the PET-negative group. RESULTS: There were no statistically significant differences in baseline, perioperative, or pathologic characteristics between the 2 groups except HBsAg titer, tumor size, and presence of bile duct tumor thrombi. Multivariate analysis showed that tumor size >3.5 cm and HBsAg titer >1,000 cutoff index were predisposing factors of positive PET-CT. Disease-free survival and overall survival rate at 1, 3, and 5 years were 76.3%, 64.4%, 60.3% and 96.8%, 91.1%, 85.1% in the PET-negative group, respectively, compared with 70.7%, 62.2%, 58.9% and 98.5%, 97.0%, 97.0% in the PET-positive group (P = 0.547 and P = 0.046). Multivariate analysis showed that positive PET-CT was closely associated with increased patient survival, but was not related to HCC recurrence. CONCLUSION: These results suggest that positive PET findings are not a predisposing factor for recurrence of HBV-related HCC patients, but appear to be associated with improved patient survival. Further prospective studies are needed to confirm the prognostic value of 18F-FDG PET in these patients.
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WPRIM
Assunto principal:
Prognóstico
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Recidiva
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Ductos Biliares
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Vírus da Hepatite B
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Causalidade
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Análise Multivariada
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Taxa de Sobrevida
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Estudos Prospectivos
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Carcinoma Hepatocelular
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Intervalo Livre de Doença
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Annals of Surgical Treatment and Research
Ano de publicação:
2018
Tipo de documento:
Article