Long-term Survival Benefit of Statin in Patients with Coronary Chronic Total Occlusion without Revascularization
Journal of Korean Medical Science
;
: e134-2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-714078
ABSTRACT
BACKGROUND:
Limited data are available on the efficacy of statin therapy in stable ischemic heart disease with chronic total occlusion (CTO) without revascularization. We investigated whether statin therapy could be beneficial in stable patients with CTO without revascularization.METHODS:
From March 2003 to February 2012, 2,024 patients with at least one CTO were enrolled in a retrospective, single-center registry; 664 of these patients were managed conservatively without an initial revascularization strategy. Among them, we excluded CTO cases involving acute coronary syndrome, in-hospital death or incomplete data and classified 551 patients into statin (n = 369) and non-statin (n = 182) groups according to use of statin at discharge. Propensity score matching analysis was also performed in 148 pairs. The primary outcome was cardiac death.RESULTS:
The median overall follow-up duration was 45.7 months (interquartile range 19.9–70.5 months). Cardiac death occurred in 22 patients (6.0%) in the statin group vs. 24 patients (13.2%) in the non-statin group (P 70 years, renal insufficiency, prior myocardial infarction, left ventricular ejection fraction < 40%, proximal-to-mid CTO location, and no use of statin in CTO patients.CONCLUSION:
Statin therapy at discharge may be associated with a reduction in long-term cardiac mortality in stable CTO patients without revascularization.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Volume Sistólico
/
Análise Multivariada
/
Estudos Retrospectivos
/
Seguimentos
/
Mortalidade
/
Isquemia Miocárdica
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Morte
/
Insuficiência Renal
/
Síndrome Coronariana Aguda
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS