Your browser doesn't support javascript.
loading
Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder
Psychiatry Investigation ; : 86-92, 2017.
Artigo em Inglês | WPRIM | ID: wpr-71425
ABSTRACT

OBJECTIVE:

Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population.

METHODS:

In this age- and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), −1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD.

RESULTS:

No significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the −1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the −1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047).

CONCLUSION:

In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pânico / Polimorfismo Genético / Serotonina / Catecol O-Metiltransferase / Estudos de Casos e Controles / Transtorno de Pânico / Agorafobia / Receptor 5-HT1A de Serotonina / Povo Asiático / Proteínas da Membrana Plasmática de Transporte de Serotonina Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Psychiatry Investigation Ano de publicação: 2017 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pânico / Polimorfismo Genético / Serotonina / Catecol O-Metiltransferase / Estudos de Casos e Controles / Transtorno de Pânico / Agorafobia / Receptor 5-HT1A de Serotonina / Povo Asiático / Proteínas da Membrana Plasmática de Transporte de Serotonina Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Psychiatry Investigation Ano de publicação: 2017 Tipo de documento: Artigo