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Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder
Psychiatry Investigation ; : 407-412, 2018.
Artigo em Inglês | WPRIM | ID: wpr-714291
ABSTRACT

OBJECTIVE:

To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD).

METHODS:

A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the p values were corrected with the permutation test.

RESULTS:

The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05).

CONCLUSION:

The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Transtornos de Estresse Pós-Traumáticos / Reação em Cadeia da Polimerase / Análise de Sequência de DNA / Fator Neurotrófico Derivado do Encéfalo / Polimorfismo de Nucleotídeo Único / Alelos / Voluntários Saudáveis / Frequência do Gene / Genótipo Limite: Humanos Idioma: Inglês Revista: Psychiatry Investigation Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Transtornos de Estresse Pós-Traumáticos / Reação em Cadeia da Polimerase / Análise de Sequência de DNA / Fator Neurotrófico Derivado do Encéfalo / Polimorfismo de Nucleotídeo Único / Alelos / Voluntários Saudáveis / Frequência do Gene / Genótipo Limite: Humanos Idioma: Inglês Revista: Psychiatry Investigation Ano de publicação: 2018 Tipo de documento: Artigo