A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
Psychiatry Investigation
; : 402-406, 2018.
Article
em En
| WPRIM
| ID: wpr-714292
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. METHODS: A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and genotyped for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used. RESULTS: A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094). CONCLUSION: These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sítios de Ligação
/
Modelos Lineares
/
Saúde Mental
/
Receptores Dopaminérgicos
/
MicroRNAs
/
Depressão
/
Neuropsiquiatria
/
Modelos Genéticos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2018
Tipo de documento:
Article