Increased Risk of Ischemic Stroke during Sleep in Apneic Patients
Journal of Clinical Neurology
;
: 174-178, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-714339
ABSTRACT
BACKGROUND AND PURPOSE:
The literature indicates that obstructive sleep apnea (OSA) increases the risk of ischemic stroke. However, the causal relationship between OSA and ischemic stroke is not well established. This study examined whether preexisting OSA symptoms affect the onset of acute ischemic stroke.METHODS:
We investigated consecutive patients who were admitted with acute ischemic stroke, using a standardized protocol including the Berlin Questionnaire on symptoms of OSA prior to stroke. The collected stroke data included the time of the stroke onset, risk factors, and etiologic subtypes. The association between preceding OSA symptoms and wake-up stroke (WUS) was assessed using multivariate logistic regression analysis.RESULTS:
We identified 260 subjects with acute ischemic strokes with a definite onset time, of which 25.8% were WUS. The presence of preexisting witnessed or self-recognized sleep apnea was the only risk factor for WUS (adjusted odds ratio=2.055, 95% confidence interval=1.035–4.083, p=0.040).CONCLUSIONS:
Preexisting symptoms suggestive of OSA were associated with the occurrence of WUS. This suggests that OSA contributes to ischemic stroke not only as a predisposing risk factor but also as a triggering factor. Treating OSA might therefore be beneficial in preventing stroke, particularly that occurring during sleep.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndromes da Apneia do Sono
/
Berlim
/
Modelos Logísticos
/
Fatores de Risco
/
Apneia Obstrutiva do Sono
/
Acidente Vascular Cerebral
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2018
Tipo de documento:
Artigo
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