Your browser doesn't support javascript.
loading
Evolutionary course of CsRn1 long-terminal-repeat retrotransposon and its heterogeneous integrations into the genome of the liver fluke, Clonorchis sinensis
The Korean Journal of Parasitology ; : 209-219, 2003.
Artigo em Inglês | WPRIM | ID: wpr-7144
ABSTRACT
The evolutionary course of the CsRn1 long-terminal-repeat (LTR) retrotransposon was predicted by conducting a phylogenetic analysis with its paralog LTR sequences. Based on the clustering patterns in the phylogenetic tree, multiple CsRn1 copies could be grouped into four subsets, which were shown to have different integration times. Their differential sequence divergences and heterogeneous integration patterns strongly suggested that these subsets appeared sequentially in the genome of C. sinensis. Members of recently expanding subset showed the lowest level of divergence in their LTR and reverse transcriptase gene sequences. They were also shown to be highly polymorphic among individual genomes of the trematode. The CsRn1 element exhibited a preference for repetitive, agenic chromosomal regions in terms of selecting integration targets. Our results suggested that CsRn1 might induce a considerable degree of intergenomic variation and, thereby, have influenced the evolution of the C. sinensis genome.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Filogenia / Polimorfismo Genético / DNA Polimerase Dirigida por RNA / Genoma / Clonorchis sinensis / Análise de Sequência de DNA / Retroelementos / Dosagem de Genes / DNA de Helmintos / Evolução Molecular Limite: Animais Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2003 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Filogenia / Polimorfismo Genético / DNA Polimerase Dirigida por RNA / Genoma / Clonorchis sinensis / Análise de Sequência de DNA / Retroelementos / Dosagem de Genes / DNA de Helmintos / Evolução Molecular Limite: Animais Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2003 Tipo de documento: Artigo