Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission
Biomolecules & Therapeutics
; : 433-437, 2016.
Article
em En
| WPRIM
| ID: wpr-71446
Biblioteca responsável:
WPRO
ABSTRACT
Consumption of high doses of ethanol can lead to amnesia, which often manifests as a blackout. These blackouts experienced by ethanol consumers may be a major cause of the social problems associated with excess ethanol consumption. However, there is currently no established treatment for preventing these ethanol-induced blackouts. In this study, we tested the ethanol extract of the roots of Salvia miltiorrhiza (SM) for its ability to mitigate ethanol-induced behavioral and synaptic deficits. To test behavioral deficits, an object recognition test was conducted in mouse. In this test, ethanol (1 g/kg, i.p.) impaired object recognition memory, but SM (200 mg/kg) prevented this impairment. To evaluate synaptic deficits, NMDA receptor-mediated excitatory postsynaptic potential (EPSP) and long-term potentiation (LTP) in the mouse hippocampal slices were tested, as they are known to be vulnerable to ethanol and are associated with ethanol-induced amnesia. SM (10 and 100 μg/ml) significantly ameliorated ethanol-induced long-term potentiation and NMDA receptor-mediated EPSP deficits in the hippocampal slices. Therefore, these results suggest that SM prevents ethanol-induced amnesia by protecting the hippocampus from NMDA receptor-mediated synaptic transmission and synaptic plasticity deficits induced by ethanol.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Problemas Sociais
/
N-Metilaspartato
/
Potenciação de Longa Duração
/
Transmissão Sináptica
/
Potenciais Pós-Sinápticos Excitadores
/
Salvia
/
Salvia miltiorrhiza
/
Etanol
/
Amnésia
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2016
Tipo de documento:
Article