Increased Expression of Dickkopf-1 in Acral Lentiginous Melanoma / 대한피부과학회지
Korean Journal of Dermatology
;
: 259-264, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-714499
ABSTRACT
BACKGROUND:
Dickkopf-1 (DKK-1), an inhibitor of the Wnt signaling pathway, is known as an inhibitor of melanocyte proliferation. In recent studies, the expression of DKK-1 gene is reduced in melanoma and they lose their preventive role during development or progression of melanoma. There are no available data regarding the changes in DKK-1 gene expression in acral lentiginous melanoma (ALM), which is common in Asians.OBJECTIVE:
To analyze changes in DKK-1 expression in the development or progression of ALM in Koreans.METHODS:
Immunohistochemical staining using DKK-1 antibody of 13 invasive ALM, six ALM in situ, nine acral nevi, and four benign non-related palmoplantar specimens as controls were evaluated by the semi-quantitative grading scale, which is divided into three distinctive grades according to the degree of cytoplasmic staining of DKK-1.RESULTS:
Among the invasive ALM specimens, seven of 13 (53.8%) were graded as strongly positive (2+), and only one case (7.7%) was negative. In cases of ALM in situ, two specimens (33.3%) stained positive (1+) and the remaining four specimens (66.6%) were not stained. All specimens from both acral nevus and benign palmoplantar lesions, which were used as the control group, were also negative.CONCLUSION:
In contrast with recent reports, DKK-1 expression showed a positive correlation with ALM progression or invasiveness. The role of DKK-1 as a potential predictor of ALM progression warrants further study.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Expressão Gênica
/
Citoplasma
/
Povo Asiático
/
Via de Sinalização Wnt
/
Melanócitos
/
Melanoma
/
Nevo
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Dermatology
Ano de publicação:
2018
Tipo de documento:
Artigo
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