Analysis of Peripheral B Cell Subsets in Patients With Allergic Rhinitis
Allergy, Asthma & Immunology Research
;
: 236-243, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-714723
ABSTRACT
PURPOSE:
Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic rhinitis (AR) have not been well documented. This study aimed to analyze the characteristics of B cell subsets in the peripheral blood of AR patients.METHODS:
Forty-seven AR patients and 54 healthy controls were enrolled in this study, and the B cell subsets in peripheral blood of all subjects were analyzed by flow cytometry. Moreover, the serum total immunoglobulin E (IgE) and IgE concentrations secreted into the cultured peripheral blood mononuclear cells (PBMCs) were measured by using enzyme-linked immunosorbent assay.RESULTS:
We found the peripheral blood of AR patients contained higher percentages of memory B cells, plasma cells, and CD19+CD24hiCD27+ regulatory B cells (Bregs) than those of age-matched healthy controls (P < 0.05), while the percentages of naïve B cells and CD19+CD24hiCD38hi Bregs were significantly lower in AR patients than in healthy individuals (P < 0.05). In addition, the serum total IgE and IgE concentrations secreted into the cultured PBMCs were elevated in AR patients than in the healthy controls (P < 0.05).CONCLUSIONS:
Our findings indicate that AR patients were characterized by increase in terminally differentiated memory B cells or plasma cells and decreases in CD19+CD24hiCD38hi Breg cells in the peripheral blood.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasmócitos
/
Imunoglobulina E
/
Imunoglobulinas
/
Ensaio de Imunoadsorção Enzimática
/
Linfócitos B
/
Subpopulações de Linfócitos B
/
Linfócitos B Reguladores
/
Rinite Alérgica
/
Citometria de Fluxo
/
Memória
Limite:
Humanos
Idioma:
Inglês
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2018
Tipo de documento:
Artigo
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