Anti-obesity and LDL-cholesterol lowering effects of silkworm hemolymph in C57BL/6N mice fed high fat diet / 한국영양학회지
Journal of Nutrition and Health
;
: 201-207, 2018.
Artigo
em Coreano
| WPRIM
| ID: wpr-714898
ABSTRACT
PURPOSE:
Obesity, a worldwide epidemic, is associated with insulin resistance, hyperlipidemia, hypertension, cardiovascular disease, and certain cancers. Many strategies, including natural alternative anti-obesity agents, are used widely to prevent obesity. This study examined the effects of silkworm hemolymph on the weight control of C57BL/6N mice fed with a high-fat diet.METHODS:
The mice were divided into five groups normal group (N), high-fat diet group (HFC), high-fat diet and silkworm hemolymph (at dose of 1 mL/kg BW (HFS-1), 5 mL/kg BW (HFS-5) and 10 mL/kg (HFS-10) for 12 weeks.RESULTS:
After 12 weeks treatment, the administration of silkworm hemolymph decreased the final body weight significantly along with a decrease in the weights of epididymal fat and total fat. The plasma LDL-cholesterol concentration was significantly lower in the HFS-1, HFS-5, and HFS-10 groups than in the HFC group. In addition, the leptin level of the HFS groups was significantly lower than those of the HFC group without a change in the plasma insulin concentration.CONCLUSION:
These findings suggest that the silkworm hemolymph may have the potential to prevent obesity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Bombyx
/
Pesos e Medidas
/
Peso Corporal
/
Resistência à Insulina
/
Doenças Cardiovasculares
/
Hemolinfa
/
Fármacos Antiobesidade
/
Leptina
/
Dieta Hiperlipídica
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of Nutrition and Health
Ano de publicação:
2018
Tipo de documento:
Artigo
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