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Plasma CRABP2 as a Novel Biomarker in Patients with Non-Small Cell Lung Cancer
Article em En | WPRIM | ID: wpr-715018
Biblioteca responsável: WPRO
ABSTRACT
BACKGROUND: Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC). METHODS: Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network. The control specimens were from patients who were without malignancies or pulmonary diseases. We measured plasma levels of CRABP2 using commercially available enzyme-linked immunosorbent assay kits. RESULTS: The mean age of the NSCLC patients was 71.8 ± 8.9 years, and the median cigarette smoking history was 32 PY (range, 0–150 PY). Plasma CRABP2 levels were significantly higher in patients with NSCLC than in the matched controls (37.63 ± 28.71 ng/mL vs. 24.09 ± 21.09 ng/mL, P < 0.001). Higher plasma CRABP2 levels were also correlated with lower survival rates in NSCLC patients (P = 0.014). CONCLUSION: Plasma CRABP2 levels might be a novel diagnostic and prognostic marker in NSCLC.
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Texto completo: 1 Índice: WPRIM Assunto principal: Plasma / Tretinoína / Ensaio de Imunoadsorção Enzimática / Biomarcadores / Fumar / Proteínas de Transporte / Marcadores Genéticos / Taxa de Sobrevida / Mortalidade / Carcinoma Pulmonar de Células não Pequenas Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Journal of Korean Medical Science Ano de publicação: 2018 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Plasma / Tretinoína / Ensaio de Imunoadsorção Enzimática / Biomarcadores / Fumar / Proteínas de Transporte / Marcadores Genéticos / Taxa de Sobrevida / Mortalidade / Carcinoma Pulmonar de Células não Pequenas Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Journal of Korean Medical Science Ano de publicação: 2018 Tipo de documento: Article