Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
Immune Network
; : e20-2018.
Article
em En
| WPRIM
| ID: wpr-715078
Biblioteca responsável:
WPRO
ABSTRACT
IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteoblastos
/
Osteoclastos
/
Osteogênese
/
Osteoporose
/
Artrite
/
Artrite Reumatoide
/
Doenças Autoimunes
/
Espondilite Anquilosante
/
Reabsorção Óssea
/
Monócitos
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2018
Tipo de documento:
Article