Enhancement of DNA Vaccine-induced Immune Responses by Influenza Virus NP Gene
Immune Network
;
: 169-178, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-71518
ABSTRACT
DNA immunization induces B and T cell responses to various pathogens and tumors. However, these responses are known to be relatively weak and often transient. Thus, novel strategies are necessary for enhancing immune responses induced by DNA immunization. Here, we demonstrated that co-immunization of influenza virus nucleoprotein (NP) gene significantly enhances humoral and cell-mediated responses to codelivered antigens in mice. We also found that NP DNA coimmunization augments in vivo proliferation of adoptively transferred antigen-specific CD4 and CD8 T cells, which enhanced protective immunity against tumor challenge. Our results suggest that NP DNA can serve as a novel genetic adjuvant in cocktail DNA vaccination.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Orthomyxoviridae
/
DNA
/
Linfócitos T
/
Imunização
/
Vacinação
/
Influenza Humana
/
Nucleoproteínas
Limite:
Animais
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2009
Tipo de documento:
Artigo
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