Pyrazinamide-Induced Urticaria and Angioedema: a Case Report / 대한내과학회지
Korean Journal of Medicine
;
: 306-310, 2018.
Artigo
em Coreano
| WPRIM
| ID: wpr-715340
ABSTRACT
Pyrazinamide (PZA) is an anti-tuberculosis drug and an essential component of the standard four-drug regimen for tuberculosis. Here, we report a case of immediate angioedema secondary to PZA administration intended for pulmonary tuberculosis treatment. A previously healthy 48-year-old woman was diagnosed with pulmonary tuberculosis and tuberculous lymphadenitis. Thirty minutes after taking the first dose of isoniazid, rifampicin, pyrazinamide, and ethambutol, the patient developed facial edema, generalized rash, and dizziness. An oral provocation test was performed on the four drugs, and 1,000 mg pyrazinamide showed a positive result characterized by 50 minutes of urticaria, angioedema, and hypotension. As the prevalence of tuberculosis increases, prescriptions for anti-tuberculosis drugs may increase as well. Clinicians should be aware of the possibility of immediate hypersensitivity as well as delayed hypersensitivity to anti-tuberculosis drugs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pirazinamida
/
Rifampina
/
Tuberculose
/
Tuberculose dos Linfonodos
/
Tuberculose Pulmonar
/
Urticária
/
Prevalência
/
Tontura
/
Hipersensibilidade a Drogas
/
Edema
Tipo de estudo:
Estudo de prevalência
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS