Prognostic Value of TZAP Expression in Various Cancers: TCGA Data Analysis / 계명의대학술지
Keimyung Medical Journal
;
: 17-21, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-715576
ABSTRACT
The zinc finger protein ZBTB48 is a telomere-associated factor and renamed it as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres competing with TRF1 and TRF2. However, its expression in cancers has not been performed. In the present study, we analyzed the prognosis of TZAP expression in 22 kinds of cancers by using TCGA data analysis. TZAP expression had a prognostic value in cervical, colon, and pancreatic cancers. When sorting the patients differently, it got the significance in bladder, breast, kidney, brain, and lung cancers. TZAP expression was associated with better prognosis in bladder, breast, cervical, lung, and pancreatic cancers. However, it showed poorer survival results in colon, kidney, and brain cancers. This result suggested that TZAP expression appears to be a possible prognosis marker in various cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Pancreáticas
/
Prognóstico
/
Zinco
/
Bexiga Urinária
/
Encéfalo
/
Neoplasias Encefálicas
/
Mama
/
Estatística como Assunto
/
Dedos de Zinco
/
Telômero
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Keimyung Medical Journal
Ano de publicação:
2018
Tipo de documento:
Artigo
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