Phenotypic and Genomic Characterization of AmpC-Producing Klebsiella pneumoniae From Korea
Annals of Laboratory Medicine
;
: 367-370, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-715636
ABSTRACT
The prevalence of multidrug-resistant gram-negative bacteria has continuously increased over the past few years; bacterial strains producing AmpC β-lactamases and/or extended-spectrum β-lactamases (ESBLs) are of particular concern. We combined high-resolution whole genome sequencing and phenotypic data to elucidate the mechanisms of resistance to cephamycin and β-lactamase in Korean Klebsiella pneumoniae strains, in which no AmpC-encoding genes were detected by PCR. We identified several genes that alone or in combination can potentially explain the resistance phenotype. We showed that different mechanisms could explain the resistance phenotype, emphasizing the limitations of the PCR and the importance of distinguishing closely-related gene variants.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Resistência Microbiana a Medicamentos
/
Reação em Cadeia da Polimerase
/
Prevalência
/
Genoma
/
Bactérias Gram-Negativas
/
Klebsiella
/
Klebsiella pneumoniae
/
Coreia (Geográfico)
Tipo de estudo:
Estudo de prevalência
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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