Efficacy of Gaze Photographs in Diagnosing Ocular Myasthenia Gravis
Journal of Clinical Neurology
;
: 333-338, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-715691
ABSTRACT
BACKGROUND AND PURPOSE:
The various tests that are routinely used to diagnose generalized myasthenia gravis, such as the edrophonium test, serum anti-acetylcholine-receptor antibodies (AChR-Ab), and repetitive nerve stimulation (RNS) tests, have lower diagnostic sensitivity in ocular myasthenia gravis (OMG). Diagnosing OMG becomes even more difficult when the clinical symptoms are subtle. There is no gold-standard diagnostic test available for OMG patients, and so this study compared the diagnostic sensitivity of gaze photographs with conventional tests in OMG.METHODS:
Records of gaze photographs were available for 25 of 31 consecutive patients diagnosed with OMG. Each patient underwent a neuro-ophthalmologic examination, serum AChR-Ab, RNS, edrophonium test, ice tests, and the acquisition of gaze photographs. The margin reflex distance 1 (MRD1) was measured on each of the gaze photographs, with MRD1 < 2 mm or an interlid MRD1 difference of ≥2 mm on any of the gaze photographs defined as a positive sign of OMG. The diagnostic sensitivities of the tests were assessed.RESULTS:
The mean age at onset was 38.5 years (range, 2–76 years), and 13 patients (52%) were men. The diagnostic sensitivities of the RNS test, AChR-Ab test, gaze photographs, and ice test were 56%, 64%, 80%, and 73%, respectively.CONCLUSIONS:
The diagnostic sensitivity was higher for gaze photographs than for the other tests applied to OMG patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Reflexo
/
Idade de Início
/
Diagnóstico
/
Testes Diagnósticos de Rotina
/
Edrofônio
/
Gelo
/
Anticorpos
/
Miastenia Gravis
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2018
Tipo de documento:
Artigo
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