Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas
Korean Journal of Pathology
;
: 463-468, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-71578
ABSTRACT
BACKGROUND:
Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs.METHODS:
We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases).RESULTS:
An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034).CONCLUSIONS:
There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
Recidiva
/
Proteínas Tirosina Quinases
/
RNA Mensageiro
/
Reação em Cadeia da Polimerase
/
Fator de Crescimento de Hepatócito
/
Proteínas Proto-Oncogênicas c-met
/
Hepatócitos
/
Transcrição Reversa
/
Meningioma
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS