Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer's Disease / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 261-265, 2018.
Artigo
em Coreano
| WPRIM
| ID: wpr-716135
ABSTRACT
OBJECTIVES:
This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer's disease patients with psychosis (AD+P) and those without psychosis (AD−P).METHODS:
Overall, 31 AD+P patients and 29 AD−P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease. AD−P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD−P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume.RESULTS:
The hippocampal volume in AD+P was smaller than that in AD−P.CONCLUSION:
These findings suggest that AD+P is associated with a reduced hippocampal volume.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtornos Psicóticos
/
Atrofia
/
Lobo Temporal
/
Imageamento por Ressonância Magnética
/
Seguimentos
/
Demência
/
Educação
/
Doença de Alzheimer
/
Hipocampo
/
Coreia (Geográfico)
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
2018
Tipo de documento:
Artigo
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