Diagnosing Diabetic Neuropathy: Something Old, Something New
Diabetes & Metabolism Journal
; : 255-269, 2018.
Article
em En
| WPRIM
| ID: wpr-716235
Biblioteca responsável:
WPRO
ABSTRACT
There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess therapeutic benefit in clinical trials of DPN. Over the past several decades symptoms and signs, quantitative sensory and electrodiagnostic testing have been strongly endorsed, but have consistently failed as surrogate end points in clinical trials. Therefore, there is an unmet need for reliable biomarkers to capture the onset and progression and to facilitate drug discovery in DPN. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging modality for in vivo evaluation of sensory C-fibers. An increasing body of evidence from multiple centers worldwide suggests that CCM fulfills the FDA criteria as a surrogate endpoint of DPN.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
United States Food and Drug Administration
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Biomarcadores
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Doenças do Sistema Nervoso Periférico
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Microscopia Confocal
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Neuropatias Diabéticas
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Diagnóstico
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Descoberta de Drogas
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2018
Tipo de documento:
Article