Damage-Associated Molecular Patterns in Inflammatory Diseases
Immune Network
;
: e27-2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-716244
ABSTRACT
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoartrite
/
Doença de Parkinson
/
Artrite Reumatoide
/
Biomarcadores
/
Proteínas S100
/
Aterosclerose
/
Receptores de Reconhecimento de Padrão
/
Doença de Alzheimer
/
Proteínas de Choque Térmico
/
Sistema Imunitário
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS