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Olmutinib Induced Lichen Planus Like Eruption
Annals of Dermatology ; : 451-453, 2018.
Artigo em Inglês | WPRIM | ID: wpr-716501
ABSTRACT
Drug induced lichen planus like eruption is an uncommon cutaneous adverse effect of several drugs. This appears symmetric eruption of erythematous or violaceous plaques resembling lichen planus on the trunk and extremities. A 50-year-old male presented with scaly, violaceous plaques and dusky brown macules on whole body. For four months, the patient was treated with olmutinib, an oral, third-generation epidermal growth factor receptor-tyrosine kinase inhibitor. In May 2016, olmutinib received its first global approval in South Korea for the treatment of patients with locally advanced or metastatic epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer. The biopsy specimen from the patient showed features of lichen planus. We diagnosed him with olmutinib-induced lichen planus like eruption. He was treated with oral methylprednisolone and topical desoxymethasone 0.25% ointment. At the same time, olmutinib dose was decreased to three-fourths of this patient's starting dose. After that, the cutaneous lesions improved.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosfotransferases / Biópsia / Desoximetasona / Metilprednisolona / Toxidermias / Carcinoma Pulmonar de Células não Pequenas / Fator de Crescimento Epidérmico / Extremidades / Receptores ErbB / Coreia (Geográfico) Limite: Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosfotransferases / Biópsia / Desoximetasona / Metilprednisolona / Toxidermias / Carcinoma Pulmonar de Células não Pequenas / Fator de Crescimento Epidérmico / Extremidades / Receptores ErbB / Coreia (Geográfico) Limite: Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2018 Tipo de documento: Artigo