Effects of Ivabradine on Left Ventricular Systolic Function and Cardiac Fibrosis in Rat Myocardial Ischemia-Reperfusion Model / 전남의대학술지
Chonnam Medical Journal
;
: 167-172, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-716579
ABSTRACT
We evaluated the effects of Ivabradine on left ventricle (LV) ejection fraction (EF) and LV infarcted tissue in the rat myocardial ischemia-reperfusion model. Twenty rats were randomly assigned to group 1 (ischemia-reperfusion, no treatment, n=10) and group 2 (ischemia-reperfusion + Ivabradine 10 mg/kg, n=10). Ivabradine was administered for 28 days. Echocardiography was performed at 7 days and at 28 days after the induction of ischemia-reperfusion injury. Cardiac fibrosis induced by ischemia-reperfusion injury was evaluated by Masson's trichrome staining. The infarct size was quantified using the Image J program. At the 28-day follow-up, LVEF was significantly higher (36.02±6.16% vs. 45.72±2.62%, p<0.001) and fractional shortening was significantly higher (15.23±2.84% vs. 20.13±1.38%, p<0.001) in group 2 than group 1. Delta (28 day minus 7 day) EF was significantly higher in group 2 than group 1 (−4.36±3.49% vs. 4.31±5.63%, p<0.001). Also, heart rate (beats/min) was significantly lower in group 2 than group 1 (251.67±25.19 vs. 199.29±31.33, p=0.025). Group 2 had a smaller infarct size (40.70±8.94% vs. 30.19±5.89%, p<0.01) than group 1 at 28-day follow-up. Oral administration of Ivabradine could improve LV systolic function and reduce infarcted tissue area in rat myocardial ischemia-reperfusion model.
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Índice:
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Assunto principal:
Fibrose
/
Ecocardiografia
/
Traumatismo por Reperfusão Miocárdica
/
Traumatismo por Reperfusão
/
Administração Oral
/
Seguimentos
/
Isquemia Miocárdica
/
Frequência Cardíaca
/
Ventrículos do Coração
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Chonnam Medical Journal
Ano de publicação:
2018
Tipo de documento:
Artigo
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