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Effectiveness of L-asparaginase-based regimens compared to anthracycline-based regimens in newly diagnosed extranodal NK/T-cell lymphoma, nasal type: a single Mexican center experience
Blood Research ; : 210-217, 2018.
Artigo em Inglês | WPRIM | ID: wpr-716611
ABSTRACT

BACKGROUND:

Extranodal NK/T-cell lymphoma, nasal type (ENKTCL) has a high prevalence in Asia and Latin American countries, such as Mexico, where it encompasses 40% of all T-cell non-Hodgkin lymphomas. Historically, responses to anthracycline-based therapies have been disappointing. Since data about the effectiveness of L-asparaginase-based regimens in Mexico are limited, we compared both therapies in our center.

METHODS:

We performed a retrospective cohort of patients with newly diagnosed ENKTCL, who were divided into two groups for treatment and analysis (group 1 L-asparaginase-based regimen and group 2 anthracycline-based regimen) between 2001 and 2016.

RESULTS:

Of 36 patients with newly-diagnosed ENKTCL, 33 received at least one cycle of chemotherapy (22 in group 1 and 11 in group 2). Over a median follow-up interval of 17 months (range, 0–167), a complete response (CR) was observed in 45.5% of patients in group 1, compared to 27% of group 2 (P=0.45). Progression was more frequently observed in group 2 than in group 1 (54.5% vs. 18.4%, P=0.04). The median overall survival (OS) was 44 months in group 1, compared to 5 months in group 2 (P=0.012). The multivariate analysis showed that failure to achieve a CR after first-line therapy was the only significant factor for OS (HR, 3.04; 95% CI, 1.4–6.5; P=0.005).

CONCLUSION:

L-asparaginase-based regimens for patients with newly-diagnosed ENKTCL confer a survival advantage over anthracycline-based regimens.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ásia / Linfoma não Hodgkin / Linfócitos T / Prevalência / Análise Multivariada / Estudos Retrospectivos / Estudos de Coortes / Seguimentos / Tratamento Farmacológico / Linfoma Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia / México Idioma: Inglês Revista: Blood Research Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ásia / Linfoma não Hodgkin / Linfócitos T / Prevalência / Análise Multivariada / Estudos Retrospectivos / Estudos de Coortes / Seguimentos / Tratamento Farmacológico / Linfoma Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia / México Idioma: Inglês Revista: Blood Research Ano de publicação: 2018 Tipo de documento: Artigo