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Postprandial Lipid Concentrations and Daytime Biological Variation of Lipids in a Healthy Chinese Population
Annals of Laboratory Medicine ; : 431-439, 2018.
Artigo em Inglês | WPRIM | ID: wpr-717057
ABSTRACT

BACKGROUND:

Several latest guidelines and consensus statements from Europe and the United States specify that there is no need for fasting prior to routine lipid tests. However, the latest Chinese guidelines still recommend fasting tests owing to a lack of local evidence. This study aimed to investigate postprandial lipid concentrations and daytime biological variation of lipids in a healthy Chinese population.

METHODS:

Venous blood samples were collected from 41 ostensibly healthy Chinese volunteers at five time points during the day (0630, 0900, 1200, 1500, and 1830). The same batch of reagents was used to determine lipid concentrations. A nested ANOVA was performed to calculate within-subject biological variation (CVI) and between-subject biological variation (CVG).

RESULTS:

Postprandial concentrations of triglyceride were higher than fasting concentrations, with the maximum change occurring at 1200 (0.5 hours after lunch, 0.21±0.65 mmol/L difference). The daytime biological variation of triglycerides was relatively high (CVI=25%, CVG=35.9%). The postprandial concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were mostly lower than the fasting concentrations, and their daytime biological variations were relatively low (CVI=2.4–4.4%, CVG=11.8–18.7%).

CONCLUSIONS:

As most daytime lipid concentrations changed only slightly, non-fasting samples could be used for routine lipid tests. However, in cases of abnormal postprandial triglyceride concentrations, dietary factors and fasting time should be considered when interpreting the results.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Apolipoproteínas / Triglicerídeos / Estados Unidos / Voluntários / Colesterol / Jejum / Apolipoproteína A-I / Consenso / Povo Asiático / Europa (Continente) Tipo de estudo: Guia de Prática Clínica Limite: Humanos País/Região como assunto: América do Norte / Europa Idioma: Inglês Revista: Annals of Laboratory Medicine Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Apolipoproteínas / Triglicerídeos / Estados Unidos / Voluntários / Colesterol / Jejum / Apolipoproteína A-I / Consenso / Povo Asiático / Europa (Continente) Tipo de estudo: Guia de Prática Clínica Limite: Humanos País/Região como assunto: América do Norte / Europa Idioma: Inglês Revista: Annals of Laboratory Medicine Ano de publicação: 2018 Tipo de documento: Artigo