A Case of Wernicke's Encephalopathy Following Fluorouracil-based Chemotherapy
Journal of Korean Medical Science
;
: 747-750, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-71709
ABSTRACT
The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its effects on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by 5-FU is uncommon, although acute and delayed forms have been reported. Wernicke's encephalopathy is an acute, neuropsychiatric syndrome resulting from thiamine deficiency, and has significant morbidity and mortality. Central nervous system neurotoxicity such as Wernicke's encephalopathy following chemotherapy with 5-FU has been reported rarely, although it has been suggested that 5-FU can produce adverse neurological effects by causing thiamine deficiency. We report a patient with Wernicke's encephalopathy, reversible with thiamine therapy, associated with 5-FU-based chemotherapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tiamina
/
Deficiência de Tiamina
/
Encefalopatia de Wernicke
/
Imageamento por Ressonância Magnética
/
Neoplasias Nasofaríngeas
/
Doença Aguda
/
Fluoruracila
/
Antimetabólitos Antineoplásicos
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2009
Tipo de documento:
Artigo
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