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Use of dapagliflozin in patients with advanced diabetic kidney disease
Kidney Research and Clinical Practice ; : 292-297, 2018.
Artigo em Inglês | WPRIM | ID: wpr-717209
ABSTRACT
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective for overweight diabetic patients through the induction of glucosuria. However, SGLT2 inhibitors are not recommended for patients with advanced chronic kidney disease (CKD) because they may aggravate renal function and thus become less effective in controlling blood glucose in this patient population. We suggest that adequate hydration would be helpful to prevent the side effects of SGLT2 inhibitors in diabetic patients with advanced CKD. In this study, we review five cases of SGLT2 inhibitor therapy, specifically with dapagliflozin, for the treatment of diabetes mellitus in patients with advanced CKD. The patients experienced dramatic weight reduction, improved glucose control, and further benefits without aggravation of renal function.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Glicemia / Redução de Peso / Hiperuricemia / Diabetes Mellitus / Nefropatias Diabéticas / Albuminúria / Insuficiência Renal Crônica / Sobrepeso / Glucose / Obesidade Limite: Humanos Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Glicemia / Redução de Peso / Hiperuricemia / Diabetes Mellitus / Nefropatias Diabéticas / Albuminúria / Insuficiência Renal Crônica / Sobrepeso / Glucose / Obesidade Limite: Humanos Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2018 Tipo de documento: Artigo