Clinical Usefulness of Direct/Total Bilirubin Ratio
Laboratory Medicine Online
;
: 127-134, 2018.
Artigo
em Coreano
| WPRIM
| ID: wpr-717399
ABSTRACT
BACKGROUND:
The direct/total (d/t) bilirubin ratio can be used to distinguish the causes of jaundice in many patients who have increased levels of direct and indirect bilirubin. However, the reference range of the d/t ratio has not been established, hindering its clinical usefulness. This study assessed the clinical usefulness of the d/t ratio.METHODS:
Paired total bilirubin and direct bilirubin tests (N=4,357) of cholestasis, hemolytic anemia, and neonatal jaundice were evaluated. Regression analyses were performed between total bilirubin and direct bilirubin, and between total bilirubin and the d/t ratio for each disease. Theoretical correlation models were established and used to compare the regression analyses data.RESULTS:
The theoretical model and regression equation between total bilirubin and direct bilirubin displayed linear correlations for all three cholestatic diseases. The model and regression equation between total bilirubin and the d/t ratio showed reciprocal curve correlations for the cholestatic diseases. When the total bilirubin concentration exceeded approximately 10 mg/dL, the rate of change of the d/t ratio decreased and converged to a constant value between 0.7 and 0.9.CONCLUSIONS:
If the total bilirubin concentration exceeds 10 mg/dL, cholestatic diseases can be diagnosed if the d/t ratio is more than 0.7. However, if the total bilirubin concentration is lower than 10 mg/dL, cholestatic diseases should be considered even if the d/t ratio is lower than 0.7. Therefore, use of the d/t ratio with total bilirubin could prove to be valuable in clinical settings.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Valores de Referência
/
Bilirrubina
/
Colestase
/
Hiperbilirrubinemia
/
Anemia Hemolítica
/
Icterícia
/
Icterícia Neonatal
/
Modelos Teóricos
Limite:
Humanos
/
Recém-Nascido
Idioma:
Coreano
Revista:
Laboratory Medicine Online
Ano de publicação:
2018
Tipo de documento:
Artigo
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