Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease
Journal of Clinical Neurology
; : 505-512, 2018.
Article
em En
| WPRIM
| ID: wpr-717423
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE: Basal ganglia play a pivotal role in procedural memory. However, the correlation between skill learning and striatal 123I-ioflupane uptake in Parkinson's disease (PD) has not been reported previously. Our objective was to determine whether visuomotor skill learning is associated with striatal 123I-ioflupane uptake in early PD. METHODS: We designed a case–control study to assess learning and consolidation of a visuomotor learning task (mirrored drawing of star-shaped figures) performed on two consecutive days by early-PD patients (disease duration 0.18) other than the score on part III of the Movement Disorders Society Unified Parkinson's Disease Rating Scale, which was higher in the PD patients (mean±SD: 15.0±10.4 vs. 1.3±1.1, p 0.5), whereas PD patients showed a lower consolidation index for the time per trial (p=0.009). Moreover, this performance was correlated with uptake in the right caudate nucleus (Spearman's rho=0.82, p=0.007) and the right striatum (Spearman's rho=0.67, p=0.049), including when multiple linear regression adjusting for the levodopa equivalent daily dose was performed (p=0.005 for the caudate nucleus and p=0.024 for the striatum). CONCLUSIONS: This study provides evidence of a correlation between procedural memory impairment and striatal dopaminergic dysfunction in early PD.
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Assunto principal:
Ansiedade
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Doença de Parkinson
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Gânglios da Base
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Dopamina
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Levodopa
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Núcleo Caudado
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Modelos Lineares
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Tomografia Computadorizada de Emissão de Fóton Único
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Cognição
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Depressão
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Clinical Neurology
Ano de publicação:
2018
Tipo de documento:
Article