Abnormal Oculomotor Functions in Amyotrophic Lateral Sclerosis
Journal of Clinical Neurology
;
: 464-471, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-717429
ABSTRACT
BACKGROUND AND PURPOSE:
Although traditionally regarded as spared, a range of oculomotor dysfunction has been recognized in amyotrophic lateral sclerosis (ALS) patients. ALS is nowadays considered as a neurodegenerative disorder of a third compartment comprising widespread areas of extra-motor brain including cerebellum. Our objective was to perform an observational study to examine for ocular motor dysfunction in patients with ALS and for any differences between bulbar-onset and spinal-onset patients.METHODS:
Thirty two ALS patients (bulbar onset 10, spinal onset 22) underwent the standardized systemic evaluations using video-oculography.RESULTS:
Oculomotor dysfunctions such as square wave jerks, saccadic dysmetria, abnormal cogwheeling smooth pursuits and head shaking and positional nystagmus of central origin have been observed in the ALS patients at a relatively early stage. Abnormal smooth pursuits and saccadic dysmetria were increased in the bulbar-onset compared to the spinal-onset (p < 0.05).CONCLUSIONS:
These oculomotor abnormalities may be a marker of neuro-degeneration beyond motor neurons in ALS, especially in bulbar-onset disease. Future longitudinal studies of eye movement abnormalities have provided insights into the distribution and nature of the disease process.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acompanhamento Ocular Uniforme
/
Encéfalo
/
Nistagmo Fisiológico
/
Ataxia Cerebelar
/
Cerebelo
/
Estudos Longitudinais
/
Doenças Neurodegenerativas
/
Movimentos Oculares
/
Estudo Observacional
/
Cabeça
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2018
Tipo de documento:
Artigo
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