Platycodin D May Improve Acne and Prevent Scarring by Downregulating SREBP-1 Expression Via Inhibition of IGF-1R/PI3K/Akt Pathway and Modulating Inflammation with an Increase in Collagen
Annals of Dermatology
;
: 581-587, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-717764
ABSTRACT
BACKGROUND:
Although many therapeutic agents have been developed, only a few drugs are known to target multiple pathogenic factors in the treatment of acne.OBJECTIVE:
The purpose of this study was to identify a new drug candidate, platycodin D, which is a substance extracted from the root of Platycodon grandiflorum.METHODS:
Using western blotting and Cell Counting Kit-8 assay, we studied the effects of platycodin D on SEB-1 sebocytes, fibroblasts, and keratinocytes. We investigated its effects in view of lipogenesis, collagen production, anti-inflammatory activity, and dyskeratinization.RESULTS:
In SEB-1 sebocytes, platycodin D showed a sebosuppressive effect by downregulating ERK and insulin- like growth factor-1R/PI3K/Akt/sterol-regulatory element binding protein-1 signaling pathways. In addition, adiponectin, one of the adipokines responsible for sebum production, was decreased in platycodin D-treated SEB-1 sebocytes. In fibroblasts, platycodin D increased collagen production and reduced inflammation by inhibiting nuclear factor kappa B and matrix metalloproteinases. Platycodin D also showed anti-inflammatory effects on keratinocytes. It also suppressed keratin 16 expression induced by lipopolysaccharide. Furthermore, platycodin D showed no cytotoxicity on both SEB-1 sebocytes and fibroblasts.CONCLUSION:
Our data demonstrate the clinical feasibility of platycodin D for acne treatment and the prevention of acne scarring by sebosuppressive and anti-inflammatory effects, as well as through an increase in collagen levels.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sebo
/
Queratinócitos
/
Contagem de Células
/
Western Blotting
/
NF-kappa B
/
Colágeno
/
Cicatriz
/
Acne Vulgar
/
Metaloproteinases da Matriz
/
Platycodon
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2018
Tipo de documento:
Artigo
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