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Evaluation of the Interventional Approaches in the Management of Cutaneous Leishmaniasis in Jazan: An Observational Study
Annals of Dermatology ; : 575-580, 2018.
Artigo em Inglês | WPRIM | ID: wpr-717765
ABSTRACT

BACKGROUND:

Cutaneous leishmaniasis is a tropical infection of public health importance. Numerous treatment approaches are in practice with variable degree of success however its management has no universal consensus or practice guidelines to follow.

OBJECTIVE:

Analyze the management of cutaneous leishmaniasis retrospectively at a central hospital of Jazan Province, Kingdom of Saudi Arabia to identify the current treatment pattern and compare the outcomes.

METHODS:

This cross-sectional study was conducted based on the hospital records of patients who attended the dermatology clinic for cutaneous leishmaniasis during the year 2012 to 2015.

RESULTS:

Forty three patients were included in the study. There was a male preponderance (65.1%) among the patients and 60.5% of them were of pediatric age group. Monotherapy was the initial choice for 58.1% of the patients. Intralesional sodium stibogluconate (SS-IL) was the most preferred treatment for initial therapy, as monotherapy and as part of combination therapy. A complete response was achieved in 22 patients (51.2%) with initial therapy. Among the different treatment groups, SS-IL+itraconazole showed significantly higher complete response rate compared to other treatments offered as initial therapy (p<0.01). Initial SS-IL monotherapy provided complete response in 41.2% patients receiving it, while itraconazole monotherapy provided complete response in 75% and 90.9% of the patients receiving initial itraconazole+SS-IL combination therapy with achieved complete response.

CONCLUSION:

The findings and observations suggest that initial combination therapy with SS-IL+itraconazole significantly improved the complete response rates and thus reduced the need for additional or prolonged therapies.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Arábia Saudita / Leishmania tropica / Injeções Intralesionais / Registros Hospitalares / Saúde Pública / Estudos Transversais / Estudos Retrospectivos / Leishmaniose Cutânea / Leishmania major / Itraconazol Tipo de estudo: Guia de Prática Clínica / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Arábia Saudita / Leishmania tropica / Injeções Intralesionais / Registros Hospitalares / Saúde Pública / Estudos Transversais / Estudos Retrospectivos / Leishmaniose Cutânea / Leishmania major / Itraconazol Tipo de estudo: Guia de Prática Clínica / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2018 Tipo de documento: Artigo