Cord Blood Soluble fms-Like Tyrosine Kinase 1 and Placental Growth Factor in Preterm Infants with Maternal Preeclampsia / 이화의대지
The Ewha Medical Journal
;
: 118-125, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-71800
ABSTRACT
OBJECTIVES:
The purpose of this study was to investigate the relationship of cord blood levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) in preterm infants with maternal preeclampsia.METHODS:
Thirty six preterm infants born at Ewha Womans University Mokdong Hospital from January 2006 to August 2006 were studied after prior parental consent at mid-pregnancy. sFlt-1, PlGF, and VEGF levels in the cord blood of preterm neonate, with or without maternal preeclampsia, were measured using enzyme-linked immunosorbent assay.RESULTS:
There was no difference in sFlt-1 between infants with and without maternal preeclampsia. Infants with maternal preeclampsia had significantly lower PlGF levels (P=0.035) and higher sFlt-1/PlGF ratio (P=0.080) with borderline significance. Cord blood VEGF levels were not related to maternal preeclampsia. Infants with maternal preeclampsia had lower birth weight (P=0.030), lower neonatal platelet count without statistical significance (P=0.064) and more likely to be small for gestational age (P=0.057). Neonatal platelet count was significantly correlated with cord blood PlGF levels (r=0.674, P=0.032).CONCLUSION:
Increased sFlt-1/PlGF ratio and decreased PlGF may not only be related to the pathophysiology of maternal preeclampsia but also affect the neonatal platelet count and birth weight.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Contagem de Plaquetas
/
Pré-Eclâmpsia
/
Peso ao Nascer
/
Recém-Nascido Prematuro
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Consentimento dos Pais
/
Fator A de Crescimento do Endotélio Vascular
/
Sangue Fetal
Limite:
Feminino
/
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Coreano
Revista:
The Ewha Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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