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New Helicobacter pylori Eradication Therapies / 대한소화기학회지
The Korean Journal of Gastroenterology ; : 237-244, 2018.
Artigo em Coreano | WPRIM | ID: wpr-718002
ABSTRACT
While the prevalence of Helicobacter pylori (H. pylori) infection is decreasing in Korea, the incidence of gastric cancer remains high, emphasizing the importance of H. pylori eradication. A new treatment strategy is needed as the eradication rate with standard triple therapy, which is currently the standard first-line regimen for H. pylori infection, has decreased below the optimum level. The major cause of eradication failure is increased antibiotic resistance. Sequential, concurrent, and hybrid therapies that include clarithromycin produce higher eradication rates than conventional standard triple therapy. However, the effectiveness of these treatments is limited in regions where the resistance rate to various antibiotics is high. Bismuth quadruple therapy is another alternative therapy, but again the eradication rate is not sufficiently high. Tailored therapy based on individual characteristics, including antibiotic susceptibility, may be ideal, but there are several limitations for clinical application and further research is needed. New potassium-competitive acid blocker-based therapies could emerge as effective alternatives in the near future. A consensus is needed to establish a strategy for applying new eradication therapies in Korea.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Gástricas / Bismuto / Resistência Microbiana a Medicamentos / Incidência / Prevalência / Helicobacter pylori / Helicobacter / Claritromicina / Consenso / Coreia (Geográfico) Tipo de estudo: Guia de Prática Clínica / Estudo de incidência / Estudo de prevalência / Estudo prognóstico País/Região como assunto: Ásia Idioma: Coreano Revista: The Korean Journal of Gastroenterology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Gástricas / Bismuto / Resistência Microbiana a Medicamentos / Incidência / Prevalência / Helicobacter pylori / Helicobacter / Claritromicina / Consenso / Coreia (Geográfico) Tipo de estudo: Guia de Prática Clínica / Estudo de incidência / Estudo de prevalência / Estudo prognóstico País/Região como assunto: Ásia Idioma: Coreano Revista: The Korean Journal of Gastroenterology Ano de publicação: 2018 Tipo de documento: Artigo