Prognostic Value of Biochemical Response Models for Primary Biliary Cholangitis and the Additional Role of the Neutrophil-to-Lymphocyte Ratio
Gut and Liver
; : 714-721, 2018.
Article
em En
| WPRIM
| ID: wpr-718115
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: Recently reported prognostic models for primary biliary cholangitis (PBC) have been shown to be effective in Western populations but have not been well-validated in Asian patients. This study aimed to compare the performance of prognostic models in Korean patients and to investigate whether inflammation-based scores can further help in prognosis prediction. METHODS: This study included 271 consecutive patients diagnosed with PBC in Korea. The following prognostic models were evaluated: the Barcelona model, the Paris-I/II model, the Rotterdam criteria, the GLOBE score and the UK-PBC score. The neutrophil-to-lymphocyte ratio (NLR) was analyzed with reference to its association with prognosis. RESULTS: For predicting liver transplant or death at the 5-year and 10-year follow-up examinations, the UK-PBC score (areas under the receiver operating characteristic curve [AUCs], 0.88 and 0.82) and GLOBE score (AUCs, 0.85 and 0.83) were significantly more accurate in predicting prognosis than the other scoring systems (all p 2.46) at baseline was an independent predictor of reduced transplant-free survival in the multivariate analysis (adjusted hazard ratio, 3.74; p < 0.01). When the NLR was applied to the prognostic models, it significantly differentiated the prognosis of patients. CONCLUSIONS: The UK-PBC and GLOBE scores showed good prognostic performance in Korean patients with PBC. In addition, a high NLR was associated with a poorer prognosis. Including the NLR in prognostic models may further help to stratify patients with PBC.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Prognóstico
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Colangite
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Análise Multivariada
/
Curva ROC
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Seguimentos
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Povo Asiático
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Coreia (Geográfico)
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Fígado
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Cirrose Hepática Biliar
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2018
Tipo de documento:
Article