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The Prevalence of Cerebral Microbleeds in Non-Demented Parkinson's Disease Patients
Journal of Korean Medical Science ; : e289-2018.
Artigo em Inglês | WPRIM | ID: wpr-718195
ABSTRACT

BACKGROUND:

Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated.

METHODS:

We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated.

RESULTS:

Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1% vs. 8.8%; odds ratio [OR], 2.126; P = 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7% vs. 5.9%; OR, 2.234; P = 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1% vs. 8.9%; OR, 2.759; P = 0.010) and lobar area (14.6% vs. 4.9%; OR, 3.336; P = 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs.

CONCLUSION:

We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Encéfalo / Imageamento por Ressonância Magnética / Razão de Chances / Prevalência / Fatores de Risco Tipo de estudo: Estudo de etiologia / Estudo de prevalência / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Encéfalo / Imageamento por Ressonância Magnética / Razão de Chances / Prevalência / Fatores de Risco Tipo de estudo: Estudo de etiologia / Estudo de prevalência / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2018 Tipo de documento: Artigo