Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
Obstetrics & Gynecology Science
;
: 662-668, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-718355
ABSTRACT
OBJECTIVE:
This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL).METHODS:
We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing.RESULTS:
Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P < 0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01–17.00).CONCLUSION:
The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Papillomaviridae
/
Fumar
/
Modelos Logísticos
/
Epidemiologia
/
Fatores de Risco
/
Estudos de Coortes
/
Seguimentos
/
Papillomavirus Humano 16
/
Testes de DNA para Papilomavírus Humano
/
Células Escamosas Atípicas do Colo do Útero
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Obstetrics & Gynecology Science
Ano de publicação:
2018
Tipo de documento:
Artigo
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