Does Serum Osmolarity Change as a Result of the Reflex Neuroprotective Mechanism of Cerebral Osmo-Regulation after Minor Head Trauma?
Journal of Korean Neurosurgical Society
;
: 151-156, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-71872
ABSTRACT
OBJECTIVE:
It is well known that changes in cerebral hemodynamics occur after traumatic brain injury (TBI). Osmo-regulation in the brain is important for maintaining a constant milieu in the central nervous system. Nevertheless, to our knowledge, early osmolarity changes after minor head injury have not been studied until now.METHODS:
In this study, serum osmolarity was measured in 99 patients with minor head trauma. As a control group, blood samples were drawn from 99 patients who had a minor trauma in an extremity. Serum osmolarity was estimated using a fully automatic biochemical autoanalyzer within the first 3 hours after the trauma.RESULTS:
The mean serum osmolarity levels were 286.08+/-10.17 mOsm/L in the study group and 290.94+/-5.65 mOsm/L in the control group (p<0.001). However, after age adjustment between the study and control groups, this statistical significance was found to be valid only for patients over 30 years of age.CONCLUSION:
It was noted that serum osmolarity levels decrease in the first 3 hours following minor head trauma in patients over 30 years of age. Further studies into this area could provide guidance for the management/treatment of elderly patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Concentração Osmolar
/
Reflexo
/
Encéfalo
/
Lesões Encefálicas
/
Biomarcadores
/
Sistema Nervoso Central
/
Extremidades
/
Cabeça
/
Traumatismos Craniocerebrais
/
Hemodinâmica
Tipo de estudo:
Guia de Prática Clínica
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2009
Tipo de documento:
Artigo
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