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Female Sex and Right-Sided Tumor Location Are Poor Prognostic Factors for Patients With Stage III Colon Cancer After a Curative Resection
Annals of Coloproctology ; : 286-291, 2018.
Article em En | WPRIM | ID: wpr-718753
Biblioteca responsável: WPRO
ABSTRACT
PURPOSE: Stage-IIIC colon cancer is an advanced disease; however, its oncologic outcomes and prognostic factors remain unclear. In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC colon cancer. METHODS: From a multicenter database, we retrospectively enrolled 611 patients (355 men and 256 women) who had undergone a potentially curative resection for a stage-IIIC colon adenocarcinoma between 2003 and 2011. The primary end-point was the 5-year DFS. RESULTS: The median age was 62 years; 213 and 398 patients had right-sided colon cancer (RCC) and left-sided colon cancer (LCC), respectively. The 5-year DFS in all patients was 52.0%; median follow-up time was 35 months (range, 1–134 months). A multivariate Cox regression revealed that female sex (hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.19–1.90; P < 0.01), right-sided tumor location (HR, 1.65; 95% CI, 1.29–2.11; P < 0.01), lymphatic invasion (HR, 1.52; 95% CI, 1.08–2.15; P < 0.01) and a high (≥0.4) metastatic lymph node ratio (HR, 3.72; 95% CI, 2.63–5.24; P < 0.01) were independent predictors of worse 5-year DFS. Female patients with RCC were 1.79 fold more likely to experience recurrence than male patients with LCC. CONCLUSION: Female sex and right-sided tumor location are associated with higher tumor recurrence rates in patients with stage-IIIC colon cancers. Aggressive treatment and close surveillance should be planned for patients in these groups.
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Texto completo: 1 Índice: WPRIM Assunto principal: Prognóstico / Recidiva / Adenocarcinoma / Estudos Retrospectivos / Seguimentos / Colo / Neoplasias do Colo / Intervalo Livre de Doença / Colo Ascendente / Colo Descendente Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Annals of Coloproctology Ano de publicação: 2018 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Prognóstico / Recidiva / Adenocarcinoma / Estudos Retrospectivos / Seguimentos / Colo / Neoplasias do Colo / Intervalo Livre de Doença / Colo Ascendente / Colo Descendente Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Annals of Coloproctology Ano de publicação: 2018 Tipo de documento: Article