Mouse models of breast cancer in preclinical research / 한국실험동물학회지
Laboratory Animal Research
;
: 160-165, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-719078
ABSTRACT
Breast cancer remains the second leading cause of cancer death among woman, worldwide, despite advances in identifying novel targeted therapies and the development of treating strategies. Classification of clinical subtypes (ER+, PR+, HER2+, and TNBC (Triple-negative)) increases the complexity of breast cancers, which thus necessitates further investigation. Mouse models used in breast cancer research provide an essential approach to examine the mechanisms and genetic pathway in cancer progression and metastasis and to develop and evaluate clinical therapeutics. In this review, we summarize tumor transplantation models and genetically engineered mouse models (GEMMs) of breast cancer and their applications in the field of human breast cancer research and anti-cancer drug development. These models may help to improve the knowledge of underlying mechanisms and genetic pathways, as well as creating approaches for modeling clinical tumor subtypes, and developing innovative cancer therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mama
/
Neoplasias da Mama
/
Classificação
/
Metástase Neoplásica
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Laboratory Animal Research
Ano de publicação:
2018
Tipo de documento:
Artigo
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