Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility
Annals of Laboratory Medicine
;
: 3-14, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-719654
ABSTRACT
Thyroid disorders are common, affecting more than 10% of people in the US, and laboratory tests are integral in the management of these conditions. The repertoire of thyroid tests includes blood tests for thyroid-stimulating hormone (TSH), free thyroxine, free triiodothyronine, thyroglobulin (Tg), thyroglobulin antibodies (Tg-Ab), thyroid peroxidase antibodies (TPO-Ab), TSH receptor antibodies (TRAb), and calcitonin. TSH and free thyroid hormone tests are frequently used to assess the functional status of the thyroid. TPO-Ab and TRAb tests are used to diagnose Hashimoto's thyroiditis and Graves' disease, respectively. Tg and calcitonin are important tumor markers used in the management of differentiated thyroid carcinoma and medullary thyroid carcinoma (MTC), respectively. Procalcitonin may replace calcitonin as a biomarker for MTC. Apart from understanding normal thyroid physiology, it is important to be familiar with the possible pitfalls and caveats in the use of these tests so that they can be interpreted properly and accurately. When results are discordant, clinicians and laboratorians should be mindful of possible assay interferences and/or the effects of concurrent medications. In addition, thyroid function may appear abnormal in the absence of actual thyroid dysfunction during pregnancy and in critical illness. Hence, it is important to consider the clinical context when interpreting results. This review aims to describe the above-mentioned blood tests used in the diagnosis and management of thyroid disorders, as well as the pitfalls in their interpretation. With due knowledge and care, clinicians and laboratorians will be able to fully appreciate the clinical utility of these important laboratory tests.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Tireoglobulina
/
Testes de Função Tireóidea
/
Glândula Tireoide
/
Tireoidite
/
Tiroxina
/
Tri-Iodotironina
/
Receptores da Tireotropina
/
Calcitonina
/
Neoplasias da Glândula Tireoide
Tipo de estudo:
Estudo diagnóstico
Limite:
Gravidez
Idioma:
Inglês
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
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