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Promyelocytic Leukemoid Reaction: Unusual Findings in a Patient with Sepsis
Laboratory Medicine Online ; : 26-29, 2019.
Artigo em Coreano | WPRIM | ID: wpr-719664
ABSTRACT
Neutrophilic leukemoid reaction may occur in many situations, including hemolysis, malignancy, infection, and exposure to certain toxins. It usually shows morphological overlap with chronic myeloid leukemia in which promyelocytes are not majorly associated. Here, we present a case of promyelocytic leukemoid reaction in a patient with sepsis. A 28-year-old man was admitted for renal stone removal. After percutaneous nephrolithotomy, his condition deteriorated with fever (37.8℃), tachycardia (130/min), acute renal failure, pleural effusion, and pulmonary edema. Complete blood count indicated a white blood cell count of 73.39×10⁹/L including 82% promyelocytes, hemoglobin 8.9 g/dL, and platelet count of 85×10⁹/L. A bone marrow aspirate showed that promyelocytes accounted for 73.8% of all nucleated cells. Following bone marrow examination, treatment with all-trans retinoic acid (ATRA) was started immediately. Reverse transcription polymerase chain reaction (RT-PCR) study revealed the absence of PML-RARA (promyelocytic leukemia-retinoic acid receptor alpha) and other RARA (retinoic acid receptor alpha) rearrangements. Once the chromosome analysis of bone marrow cells demonstrated the normal karyotype, ATRA was discontinued.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Contagem de Plaquetas / Derrame Pleural / Edema Pulmonar / Taquicardia / Tretinoína / Contagem de Células Sanguíneas / Medula Óssea / Exame de Medula Óssea / Nefrostomia Percutânea / Células da Medula Óssea Tipo de estudo: Estudo diagnóstico Limite: Adulto / Humanos Idioma: Coreano Revista: Laboratory Medicine Online Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Contagem de Plaquetas / Derrame Pleural / Edema Pulmonar / Taquicardia / Tretinoína / Contagem de Células Sanguíneas / Medula Óssea / Exame de Medula Óssea / Nefrostomia Percutânea / Células da Medula Óssea Tipo de estudo: Estudo diagnóstico Limite: Adulto / Humanos Idioma: Coreano Revista: Laboratory Medicine Online Ano de publicação: 2019 Tipo de documento: Artigo