Single Center Experience of Allogeneic Peripheral Blood Stem Cell Transplantation for Acute Myeloid Leukemia / 대한혈액학회지
Korean Journal of Hematology
;
: 16-22, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-720095
ABSTRACT
BACKGROUND:
Recently, peripheral blood (PB) stem cells have been used widely for allogeneic stem cell transplantation (SCT), instead of bone marrow (BM). The current study analyzed the outcome of allogeneic PBSCT for the patients with acute myeloid leukemia (AML).METHODS:
Twenty-nine patients with AML excluding AML M3 were included for the analysis. PB stem cells were collected from HLA-matched sibling donors mobilized with G-CSF with or without GM-CSF.RESULTS:
Engraftment for neutrophil and platelet were achieved in a median 15.0 days and 14.0 days, respectively. The incidence of grade II~III acute graft versus host disease (GVHD) was 82.8% (24/29 patients), while of chronic GVHD 78.6% (22/28 patients, limited 11, extensive 11). During the median follow-up of 340 days (range, 86~1,603 days), 3 years overall survival and disease free survival was 51.4% and 40.0%, respectively.CONCLUSION:
PB may be considered as a feasible source of allogeneic SCT for patients with AML.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco
/
Doadores de Tecidos
/
Plaquetas
/
Medula Óssea
/
Leucemia Mieloide Aguda
/
Leucemia Promielocítica Aguda
/
Incidência
/
Seguimentos
/
Fator Estimulador de Colônias de Granulócitos
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Ano de publicação:
2004
Tipo de documento:
Artigo
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