A Case of Heparin Induced Thrombocytopenia with Circulating Anti-PF4/Heparin Antibody
Korean Journal of Hematology
;
: 67-70, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-720134
ABSTRACT
Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. Circulating anti-PF4/heaprin antibody (IgG, IgA and IgM) was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France) in a 61-yearold man with coronary artery disease and dyspnea on exercise. He had undergone a coronoary angiography using 2,000 unit of heparin before a procedure. On admission, laboratory testing revealed a platelet count of 296x10(9)/L and aPTT (activated partial thromboplastin time) of 38.1 sec. The fall in the platelet count was progressive, resulting in 42% and 53% of platelet counts on the 6th and 12th days after intravenous heparin administration, respectively. He was discharged after coronary artery bypass graft. On discharge, platelet count was normalized to be 212x10(9)/L. On the 7th day after dischage, anti-PF4/heaprin antibody was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Contagem de Plaquetas
/
Trombocitopenia
/
Doença da Artéria Coronariana
/
Imunoglobulina A
/
Tromboplastina
/
Ensaio de Imunoadsorção Enzimática
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Angiografia
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Heparina
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Ativação Plaquetária
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Ponte de Artéria Coronária
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Ano de publicação:
2007
Tipo de documento:
Artigo
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