Tumor Lysis Syndrome in Lymphoblastic Crisis of CML
Korean Journal of Hematology
;
: 119-123, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-720232
ABSTRACT
Tumor lysis syndrome (TLS) defines the metabolic derangements that occur with tumor breakdown following the initiation of cytotoxic therapy. TLS results from the rapid destruction of malignant cells and the abrupt release of intracellular materials and their metabolites into the extracellular space. The syndrome causes hyperuricemia, hyperkalemia, hyperphosphatemia, secondary hypocalcemia and uremia. It can result in acute renal failure and be fatal. Early recognition of patient at risk and preventive measures are important. There is a high incidence of TLS in tumors with high proliferative rates and large burden such as acute lymphoblastic leukemia and Burkitt's lymphoma. It less commonly occurs in solid tumors such as testicular cancer, breast cancer and small cell lung cancer. There are only a few reports on TLS complicated in CML in blast crisis. So we report a 45-yr-old woman presenting with TLS associated with CML in lymphoblastic crisis after the initiation of cytotoxic chemotherapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Testiculares
/
Uremia
/
Neoplasias da Mama
/
Síndrome de Lise Tumoral
/
Crise Blástica
/
Incidência
/
Linfoma de Burkitt
/
Hiperuricemia
/
Tratamento Farmacológico
/
Espaço Extracelular
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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