Low-dose All-trans Retinoic Acid for Remission Induction of Acute Promyelocytic Leukemia in Acute Renal Failure
Korean Journal of Hematology
;
: 105-109, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-720235
ABSTRACT
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Renal involvement sometimes necessitates a dose reduction or discontinuation of induction therapy for hematological malignancies. We report here on a case of APL that achieved complete remission with low-dose ATRA treatment despite the patient's acute renal failure. A 42-year-old woman presented with a 2 month history of ecchymosis and she was subsequently diagnosed with APL. During induction treatment with ATRA and idarubicin, oliguria developed and her azotemia rapidly progressed. Because of the progressive deterioration in her general condition, the patient was transferred to the intensive care unit. We started renal replacement therapy for her acute renal failure and we discontinued ATRA treatment. Her urine output started to increase, and there was an improvement in the patient's general condition. We resumed low-dose ATRA treatment. She achieved complete remission after 52 days of treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligúria
/
Tretinoína
/
Indução de Remissão
/
Idarubicina
/
Leucemia Promielocítica Aguda
/
Terapia de Substituição Renal
/
Neoplasias Hematológicas
/
Equimose
/
Insuficiência Renal
/
Azotemia
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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