A Novel Jumping Translocation of 12q21 in a Patient with Chronic Idiopathic Myelofibrosis
Korean Journal of Hematology
;
: 99-104, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-720236
ABSTRACT
Jumping translocation (JT) has been defined as the translocation involving one donor chromosome and multiple recipient chromosomes in different cell lines in the same patient. This is rarely observed in various hematologic malignancies. Chronic idiopathic myelofibrosis (CIMF) is considered to be a clonal hematopoietic stem cell disorder, and clonal cytogenetic abnormalities have been reported to occur in about 30~60% of patients. We report here on a case of CIMF with JT involving 12q21; t(5;12)(q13;q21) and t(12;12)(p13;q21) as the sole aberration. A pathogenetic relation between CIMF and the 12q rearrangement has been suggested in the literature, but neither the JT in CIMF nor the JT of 12q21 has been reported on. This is the first report of JT involving 12q21 in a patient with CIMF (ED note nice writing).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doadores de Tecidos
/
Células-Tronco Hematopoéticas
/
Linhagem Celular
/
Aberrações Cromossômicas
/
Neoplasias Hematológicas
/
Mielofibrose Primária
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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